Smriti Agrawal:

Research interests or projects

Education:

Masters degree in Biology at Lakehead University in 1999
worked at the University of Michigan, Ann Arbor, MI as a research assistant for 3 years
phD degree in the department of experimental pathology at Lund University Sweden, which I defended in May 2006

Funding:

Postdoctoral fellowship from Multiple Sclerosis society of Canada (2006-2008)
post doctoral fellowship from Alberta Heritage Foundation for Medical Research (2007-2008)

Publications:

2007

Yong VW, Agrawal SM, Stirling DP.(2007) Targeting MMPs in acute and chronic neurological conditions. Neurotherapeutics. 2007 Oct;4(4):580-9.
Agrawal SM, Lau L, Yong VW.(2007) MMPs in the central nervous system: Where the good guys go bad. Semin Cell Dev Biol. 2007 Jun 19; [Epub ahead of print]
Agrawal SM., and Yong VW. Immunopathogenesis of Multiple Sclerosis (2007) Int Rev Neurobiol. 2007;79C:99-126.
Yong V., Zabad R., Agrawal S., Gonsalves DaSilva A., Metz L., Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. (2007) Jour. Neurol. Sci. Aug 15;259(1-2):79-84. Epub 2007 Mar 23

2006

Agrawal, S. M. Role of Matrix Metalloproteinases in Leukocyte Transmigration in Murine Experimental Autoimmune Encephalomyelitis (2006) ISBN 91-85481-91-2. (PhD Thesis)
Agrawal, S., Anderson, P., Durbeej, M., Rooijen, N. Van., Ivars, F., Opdenakker, G., Sorokin, L. (2006) Dystroglycan is Selectively Cleaved at the Parenchymal Basement Membrane at Sites of Leukocyte Extravasation in Experimental Autoimmune Encephalomyelitis. J. Exp. Med. 203: 1007-1019

2003

McCullumsmith R.E, Stincic T.L, Agrawal S.M, and Meador-Woodruff J.H (2003), Differential Effects Of Antipsychotics On Haloperidol-Induced Vacuous Chewing Movements And Subcortical Gene Expression In The Rat. Eur. J.Pharmacol.

2000

Agrawal S.M and Omeljaniuk R.J (2000), Specific Binding Of [3H] Ketanserin To 5-HT2-Like Receptors In Hypothalamus Membrane Of Juvenile Trout (O. mykiss) Can. Jour. Physiol. Pharmacol. Vol 7, 1: 58-62.
Agrawal S.M and Omeljaniuk R.J (2000), Correlation Of 5-HT And Specifically Bound [3H] Ketanserin In Brain Regions Of Juvenile And Sexually Recrudescing Female Rainbow Trout (O. mykiss) Can. Jour. Physiol. Pharmacol, Vol 7, 3:228-236.

Smriti Agrawal Research interests or projects:

My main research interest is investigating the complications that underlie neuroinflammation.
During my phD I focused primarily on the roles of matrix metalloproteinases (MMPs) in the central nervous system
during an inflammatory response. Specifically, I used an animal model for the human disease multiple sclerosis (MS),
experimental autoimmune encephalomyelitis (EAE) to determine the importance of MMP-2 and -9 in leukocyte
extravasation through the blood-brain barrier, I also showed the specific cleavage of dystroglycan (a receptor on
astrocyte end-feet at the blood-brain barrier) by MMPs.
For my post doctoral research I am utilizing the mouse EAE model to investigate the roles of EMMPRIN (basigin, OX47, CD147),
and early MMP inducer, as well as ADAM-12, in the effector, and relapse-remitting phases of EAE. I am hoping to achieve a
better understanding of the timing and extent of MMP specific damage caused in EAE, and utilize this knowledge to design
better therapeutics and early detection methods in MS.

Please use this form to contact me.