V Wee yong lab calgary
     

Angelika Goncalves DaSilva, BSc, M.Sc

DaSilva A

Education:

  • BSc Honoours Neuroscience 2001 Carleton University
  • MSc Neuroscience 2003 Carleton University

Research interests or projects:

My PhD focuses on the role of matrix metalloproteinase 12 (MMP-12) in the development of experimental autoimmune encephalomyelitis (EAE) an animal
model of multiple sclerosis (MS). Specifically, we are interested in understanding the biological mechanisms that underlie disease progression
with the ultimate goal of creating better MS therapeutics. In this regard, we are investigating the role of MMP-12 cleaved substrates such
as OPN in EAE and how this effects disease progression and autoimmune function

Publications:

  • Yong V., Zabad R., Agrawal S., Gonsalves DaSilva A., Metz L., Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators. (2007) Jour. Neurol. Sci. Aug 15;259(1-2):79-84. Epub 2007 Mar 23
  • Larsen PH, Goncalves DaSilva A, Conant K, Yong VW, Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice, J Neurosci 26:2207-2214, 2006 ( See the Publication )
  • Weaver A, Goncalves da Silva A, Nuttall RK, Edwards DR, Shapiro SD, Rivest S, Yong VW., An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization. FASEB J. 2005 Oct;19(12):1668-70. Epub 2005 Aug 4.
  • Gilby KL, Da Silva AG, McIntyre DC., Differential GABA(A) subunit expression following status epilepticus in seizure-prone and seizure-resistant rats: a putative mechanism for refractory drug response. Epilepsia. 2005;46 Suppl 5:3-9.