V Wee yong lab calgary
     

Shuhong Liu:

S. Liu

Education:

  • M. Sc. degree in Molecular biology
  • Ph. D. in Virology

Research interests or projects:

My research interests are focused on the neuroprotection mechanisms of interested drugs which may potentially benefit the MS patients. One of my major projects is to explore the novel protective mechanisms of minocycline using microarrays and other molecular techniques.

Publications:

2006

  • Sarkar, S., Nuttal RK, Liu S., Edwards DR., Yong VW. Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12. Cancer Research 66(24):11771-80, 2006
  • Peng, PL, Zhong X, Tu W, Soundarapandian MM, Molner P, Zhu D, Lau L, Liu S, Liu F, Lu Y. ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. Neuron 49(5): 719-733, 2006
  • Zhu, Y., J. Antony, S. Liu, JA Martine, F. Giulian, D. Zochodne, and C Power. CD8+ lymphocyte-mediated injury of dorsal root ganglion neurons during lentivirus infection: CD154-dependent cell contact neurotoxicity. Journal of Neuroscience. 26(13):3396-403, 2006
  • Nooebakhsh, F., Q. Tang, S. Liu, C. Silva, G. van Marle and C. Pwer. Lentivirus envelope proteins exert differential neuropathogenic effects depending on neural cell type and stage of infection. Virology. 348(2): 260-76, 2006

2005

  • Zhu, Y., Jones G, Tsutsui S, Opii W, Liu S, Silva C, Butterfield DA, Power C. Lentivirus infection causes neuroinflammation and neuronal injury in dorsal root ganglia: pathogenic effects of STAT-1 and inducible nitric oxide synthase. Journal of Immunology. 2005 Jul 15;175(2):1118-26.
  • Luo CX, Zhu XJ, Zhang AX, Wang W, Yang XM, Liu SH, Han X, Sun J, Zhang SG, Lu Y, Zhu DY. Blockade of L-type voltage-gated Ca channel inhibits ischemia-induced neurogenesis by down-regulating iNOS expression in adult mouse. Journal of Neurochemstry. 94(4):1077-86, 2005

2004

  • Liu, S., L. Lau, J. Wei, D. Zhu, S. Zou, H. Sun, Y. Fu, F. Liu and Y. Lu. Expression of Ca+-permeable AMPA receptor channels primes cell death in transient forebrain ischemia. Neuron 43, 43-55, 2004
  • Zhu, D., L. Lau, S. Liu, J. Wei and Y. Lu. Activation of cAMP-response-element binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus. PNAS ,101(25): 9453-9457, 2004

2003

  • Wang J, S. Liu, Y Fu, J Wang and Y. Lu. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylation NMDA receptors. Natrue Neuroscience 6(10), 1039-1047, 2003
  • Wang, J., S. Liu, U. Haditsch, W. Tu, K. Cochrane, G. Ahmadian, H. S. Sun, L. Tran, J. Paw, B. Perrino, Y. Wang, I. Mansuy, M. M. Salter and Y. Lu. Interaction of calcineurin and GABAAR-?2s subunits produces long-term depression at CA1 inhibitory synapses. Journal of Neuroscience 23(3), 826-836, 2003. First two authors equally contribute to this work.
  • Liu, S., J. Wang, D. Zhu, Y. Fu and Y. Lu. Generation of functional inhibitory neurons in the adult rat hippocampus. Journal of Neuroscience 23(3), 732-726, 2003
  • Zhu, D., S. Liu, H. Sun, and Y. Lu. Expression of inducible nitric oxide synthase (iNOS) after focal cerebral ischemia stimulates neurogenesis in the adult rodent dentate gyrus. Journal of Neuroscience 23(1), 223-229, 2003

2001

  • Wang, S., S. Liu, M. Wu, Y. Geng, and C. Wood. Identification of a cellular protein that interacts and synergizes with the RTA (ORF50) protein of kaposi's sarcoma-associated herpesvirus in transcriptional activation. Journal of Virology 75(24): 11961-73, 2001
  • Wang, S., S. Liu, M. Wu, Y. Geng, and C. Wood. Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence. Archives of Virology 146(7):1415-26, 2001
  • Duan, W., S. Wang, S. Liu, and C. Wood. Molecular characterization of kaposi's sarcoma-associated herpesvirus/human herpesvirus-8 ORF57 promoter. Archives of Virology 146(2): 403-13, 2001

1999

  • Liu, S and Y. Geng. Proceedings of foamy viruses in molecular biology. Chinese J Virology 15(1): 84-91,1999
  • Liu, J., S. Liu, Q. Chen, and Y. Geng. Activation of bovine immunnodeficiency virus (BIV) gene expression by bovine spumavirus(BSV). Virologica Sinica 14(3):249-254, 1999
  • Wang, J.Z., S. Liu, Q. Chen, Y. Geng, and C. Wood. Comparative studies on BIV infection in China and the USA. Journal of Hebei University 19(2):170-175, 1999
  • Wang, S., S. Liu and Y. Geng. A new human herpesvirus: kaposi?s sarcoma-associated herpesvirus (KSHV). Virologica Sinica 14(1): 1-6,1999
  • Liu, J., S. Liu, Q. Chen, and Y. Geng. Borf-1 protein identified as a transcriptional trans-activator of bovine foamy virus. Chinese Science Bulletin 44(11):1017-1020, 1999

1997

  • Liu, S., H. Chen, J. Chen, Q. Chen, Y. Geng, C. Wood. Z. Qin, X. Zhao, Y. Hou, and Y. Zeng. Isolation and identification of a chinese bovine immunodeficiency virus isolate 92044. Chinese J Virology 13:(4):356-361,1997
  • Liu, S., H. Chen, J. Chen, D. Liang, Q. Chen, Y. Geng, and C. Wood. Isolation and identification of a bovine syncytial virus isolate 3026. Chinese J Virology 13(2):140-145,1997
  • Liu, S., Q. Chen, Y. Geng, and C. Wood. Transactivation of bovine immunodeficiency virus by bovine viral diarrhea virus. Chinese J Virology 13(3):229-234, 1997