Publications:

2009

Sarkar S, Yong VW, Inflammatory cytokine modulation of matrix metalloproteinase expression and invasiveness of glioma cells
in a 3-dimensional collagen matrix, J Neurooncology 91:157-164, 2009

Xue M, Fan Y, Liu S, Zygun D, Demchuk A, Yong VW, Contributions of multiple proteases to neurotoxicity in a mouse model of
intracerebral hemorrhage, Brain 132:26-36, 2009

Lu JQ, Metz L, Storek J, Yong VW, Nash RA, Joseph JT, Continued disease activity of multiple sclerosis after allogeneic
hematopoietic cell transplantation in a complete chimera: case report with histopathological findings, Arch Neurol 66:116-120, 2009

Stirling DP, Liu S, Kubes P, Yong VW, Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing
events and worsens neurological outcome, J Neurosci 29 753-764, 2009

Lu JQ, Fan Y, Mitha AP, Bell R, Metz L, Moore W, Yong VW, Association of α-synuclein immunoreactivity with inflammatory
activity in multiple sclerosis lesions, J Neuropath Exp Neurol 68:179-189, 2009

Yong VW, Prospects of repair in multiple sclerosis, J Neurol Sci 277S1:S16-S18, 2009

Goncalves DaSilva A, Yong VW, Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental
autoimmune encephalomyelitis through cytokine and chemokine dysregulation, American J Pathol 174:898-909, 2009

Xue M, Hollenberg MD, Demchuk A, Yong VW, Relative importance of proteinase-activated receptor-1 versus matrix
metalloproteinases in intracerebral hemorrhage-mediated neurotoxicity in mice, Stroke 40:2199-2204, 2009

McCreary CR, Bjarnason TA, Skihar V, Mitchell JR, Yong VW, Dunn JF, Multiexponential T₂ and Magnetization Transfer
MRI of Demyelination and Remyelination in Murine Spinal Cord, Neuroimage 45:1173-1182, 2009

KalyvasA, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G,
David S, Differing roles for members of the Phospholipase A2 superfamily in experimental autoimmune encephalomyelitis,
Brain 132:1221-1235, 2009

Ellestad K, Tsutsui S, Noorbakhsh F, Yong VW, Pittman QJ, Power C, Early life exposure to lipopolysaccaride suppresses
experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells, J Immunol 183:298-309, 2009

Metz LM, Li D, Traboulsee A, Myles ML, Duquette P, Godin J, Constantin M, Yong VW for the GA/minocycline study
investigators, Glatiramer Acetate in Combination with Minocycline in Patients with Relapsing-Remitting Multiple Sclerosis:
Results of a Canadian, Multicenter, Double-Blind, Placebo-Controlled Trial, Multiple Sclerosis, in press

Šišková Z, Yong VW, Hoekstra D, Baron W, Fibronectin perturbs process outgrowth in oligodendrocytes by misregulating MMP-9
activity, Molecular and Cellular Neuroscience, in press

Skihar V, Silva C, Chojnacki A, Doering A, Stallcup WB, Weiss S, Yong VW, Promoting oligodendrogenesis and myelin repair
using the multiple sclerosis medication glatiramer acetate, Proc Natl Acad Sci USA, in press

Yong VW, The interplay between the immune and central nervous systems in neuronal injury, Neurol (Suppl), in press

Yong VW, Rivest S, Taking advantage of the systemic immune system to cure brain diseases, Neuron, in press

Xue M, Mikliaeva E, Casha S, Zygun D, Demchuk A, Yong VW, Improving outcomes of neuroprotection by minocycline:
Guides from cell culture and intracerebral hemorrhage in mice, revised at American J Pathol

Rodrigues JC, Gonzalez GC, Zhang L, Ibrahim G, Kelly JJP, Forsyth PA, Yong VW, Parney IF, Normal human monocytes acquire
myeloid suppressor cell properties when co-cultured with glioma cells, revised at J Neuro-Oncology

Sarkar S, Yong VW, The intermediary of protein kinase C delta in tenascin C-stimulated MMP-12 expression and glioma invasiveness,
revised at Carcinogenesis

Lau L*, Cua R*, Doring A, Yong VW, Environmental cues in remyelination: Focus on the extracellular matrix and proteases,
Approved by Nature Rev Neuroscience for submission (*co-first authors)

Casha S*, Rice T*, Stirling DP*, McGowan D, Silva C, Smekal M, Gnanapavan S, Zygun D, Giovannoni G, Hurlbert J†,
Yong VW†, Markers of neuroinflammation in cerebrospinal fluid after human spinal cord injury: Temporal dynamics and
correlation with neurological recovery, submitted (*co-first authors; †co-senior authors)

Goncalves DaSilva A, Liaw L, Yong VW, Cleavage of osteopontin by matrix metalloproteinase-12 during experimental
autoimmune encephalomyelitis modulates disease severity in C57BL/6 mice, submitted

Sloka S, Silva C, Pryse-Phillips W, Patten S, Metz L, Yong VW, A quantitative analysis of suspected environmental causes of MS,
submitted

Carnini A, Hurlbert RJ, Yong VW, Casha S, Braun JEA, Reduction of PrP^C in Human Cerebrospinal Fluid after Spinal Cord Injury,
submitted

Lu JQ, Joseph JT, Nash RA, Storek J, Stevens AM, Metz L, Clark AW, Johnson ES, Yong VW, Inflammation and demyelination in
multiple sclerosis after allogeneic hematopoietic stem cell Transplantation, submitted

Bar-Or A, Reickmann P, Traboulsee A, Yong VW, Targeting Progressive Neuroaxonal Injury:
Lessons From Multiple Sclerosis, submitted

Zhang Y, Metz LM, Yong VW, Mitchell RJ, Baseline deep gray matter ‘black’ T2 predicts third-year disability in multiple sclerosis,
submitted

Sloka S, Mowbray H, Wang J, Verhaeghe B, Fan Y, Hader W, Yong VW, Normalization of microglia activity in a model of multiple
sclerosis by dipyridamole, submitted

Lau L, Cua R, Yong VW, Differential accumulation of chondroitin sulfate proteoglycans and laminins during de- and re-myelination
and their functional roles, submitted

2008

Agrawal SM, Lau L, Yong VW, MMPs in the Central Nervous System: Where the Good Guys Go Bad, Seminars Cell and Dev Biol
19:42-51, 2008

Zhang Y, Metz LM, Yong VW, Bell RB, Yeung M, Patry DG, Mitchell RJ, Pilot Trial of Minocycline in Relapsing
Remitting Multiple Sclerosis, Can J Neurol Sci 35:185-191, 2008

Stirling DP, Yong VW, Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry,
J Neurosci Res 86:1944-1958, 2008

Goncalves DaSilva A, Yong VW, Expression and regulation of matrix metalloproteinase-12 in experimental autoimmune encephalomyelitis
and in culture, J Neuroimmunol 199:24-24, 2008

Casha S, Yong VW, Midha R, Minocycline for Axonal Regeneration After Nerve Injury: A Double-Edged Sword,
editorial for Exp Neurol 213:245-248, 2008

Xue M, Yong VW, Matrix metalloproteinases in intracerebral hemorrhage, Neurol Res 30:775-782, 2008

2007

Nuttall RK, Silva C, Bar-Or A, Patel K, Edwards DR, Yong VW, Metalloproteinases (MMPs and ADAMs) are enriched in microglia compared to leukocytes and they link microglia activation with cytokine levels, GLIA 55:516-526, 2007

Gregg C, Shikar V, Larsen P, Mak G, Chojnacki A, Yong VW, Weiss S, White matter plasticity and enhanced remyelination in the maternal CNS, J Neurosci 27:1812-1823, 2007

Rice T, Larsen J, Rivest S, Yong VW, Characterization of the early neuroinflammation after spinal cord injury in mice, J Neuropath Exp Neurol 66:184-195, 2007

Zabad RK, Metz LM, Todoruk TR, Zhang Y, Mitchell JR, Yeung M, Patry DG, Bell, RM, Yong VW, The clinical response to minocycline in MS is accompanied by immune changes, Multiple Sclerosis Journal 13:517-526, 2007

Agrawal SM, Yong VW, Immunopathogenesis of multiple sclerosis, in Neurobiology of Multiple Sclerosis, Int Rev Neurobiol 79C:99-126, 2007

Yong VW, Giuliani F, Xue M, Bar-Or, Metz LM, Experimental models of neuroprotection relevant to multiple sclerosis, Neurology S32-S37, 2007

Yong VW, Zabad RK, Agrawal S, Goncalves DaSilva A, Metz LM, Elevation of Matrix Metalloproteinases (MMPs) in Multiple Sclerosis and Impact of Immunomodulators, J Neurol Sci 259:79-84, 2007

Schellenberg AE, Buist R, Yong VW, Del Bigio MR, Peeling J, Magnetic resonance imaging of blood-spinal cord barrier disruption in mice with experimental autoimmune encephalomyelitis, Mag Reson Med 58:298-305, 2007

Yong VW, Agrawal SM, Stirling DP, Targeting MMPs in acute and chronic neurological conditions, NeuroRx, special volume on Neuroimmunology in Neurotherapeutics 4:580-589, 2007

2006

Larsen PH, Goncalves DaSilva A, Conant K, Yong VW, Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice, J Neurosci 26:2207-2214, 2006

Song JH, Bellail A, Tse MC, Yong VW, Hao C, Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis, J Neurosci 26:3299-3308, 2006

Janke AD, Yong VW, Impact of IVIg on the interaction between activated T cells and microglia, Neurol Res 28:270-274, 2006

Wang CX, Song JH, Song DK, Yong VW, Shuaib A, Hao C, Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2, Cell, death and differentiation 13:1203-1212, 2006

Dhib-Jalbut S, Arnold DL, Cleveland DW, Fisher M, Friedlander RM, Mouradian MM, Przedborski S, Trapp BD, Wyss-Coray T, Yong VW, Neurodegeneration and Neuroprotection in Multiple Sclerosis and Other Neurodegenerative Diseases, J Neuroimmunol 176:198-215, 2006

Janke AD, Giuliani F, Yong VW, IVIg attenuates T cell-mediated killing of human neurons, J Neuroimmunol 177:181-188, 2006

Zhang Y, Wells J, Buist R, Peeling J, Yong VW, Mitchell JR, A novel MRI texture analysis of demyelination and inflammation in relapsing-remitting experimental allergic encephalomyelitis, Med Image Comput 9:760-767, 2006

Xue M, Hollenberg M, Yong VW, Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice, J Neurosci 26:10281-10291, 2006

Sarkar S, Nuttall RK, Edwards DR, Yong VW, Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12, Cancer Res 66:11771-11780, 2006

2005

Giuliani F, Metz LM, Wilson T, Fan Y, Bar-Or A, Yong VW, Additive effect of the combination of glatiramer acetate and minocycline in a model of MS, J Neuroimmunol 158:213-221, 2005

Wells JEA, Biernaskie J, Szymanska A, Corbett DR, Yong VW, Matrix metalloproteinase (MMP)-12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice, Eur J Neurosci 21:187-196, 2005

Giuliani F, Hader W, Yong VW, Minocycline attenuates both T cell and microglia activity to impair cytokine production in T cell - microglia interaction, J Leuk Biol 78:135-143, 2005

Giuliani F, Fu S, Metz LM, Yong VW, Effective combination of minocycline and interferon-β in a model of multiple sclerosis, J Neuroimmunol 165:83-91, 2005

Weaver A, Goncalves da Silva A, Nuttall RK, Edwards DR, Shapiro SD, Rivest S, Yong VW, An elevated matrix metalloproteinase in experimental autoimmune encephalomyelitis is protective by affecting Th1/Th2 polarization, FASEB J 19:1668-1670, 2005

Yong VW, Metalloproteinases: Mediators of pathology and regeneration in the CNS, Nature Reviews Neurosci 6:931-944, 2005

Zhou Y, Zhang J, Liu Q, Bell R, Muruve DA, Forsyth P, Arcellana-Panlilio M, Robbins S, Yong VW, The chemokine GRO-α (CXCL1) confers increased tumorigenicity to glioma cells, Carcinogenesis 26: 2058 -2068, 2005

Zhang J, Sarkar S, Yong VW, The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix

metalloproteinase, Carcinogenesis 26:2069-2077, 2005